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View Full Version : AstraZeneca COVID-19 vaccine up to 90% effective, trial results show



Teh One Who Knocks
11-23-2020, 01:22 PM
By Lee Brown - New York Post


https://i.imgur.com/60Sf8SZ.png

Britain’s AstraZeneca and Oxford University said Monday that its coronavirus vaccine has proven to be up to 90 percent effective — and can be easily distributed because it does not need to be frozen.

“These findings show that we have an effective vaccine that will save many lives,” said Oxford University Professor Andrew Pollard, the chief investigator for the drug’s trial.

AstraZeneca is the third major drug company to report glowing late-stage results for its potential COVID-19 vaccine, joining Pfizer and Moderna whose vaccines were shown to be almost 95 percent effective in trials.

But unlike those candidates, the UK drug only needs to be refrigerated rather than frozen, making it a “more practical solution for use worldwide,” according to Peter Horby, professor of Emerging Infectious Diseases and Global Health at Oxford.

“Importantly, from what we have heard the vaccine seems to prevent infection not just disease,” Horby also stressed.

“This is important as the vaccine could reduce the spread of the virus as well as protect the vulnerable from severe disease.”

AstraZeneca said it will have 200 million doses by the end of 2020, with 700 million doses ready globally by the end of the first quarter of 2021.

British Prime Minister Boris Johnson hailed the “incredibly exciting news.”

All three vaccines must be approved by regulators before they can be widely distributed.

“My suspicion is that by the time we are a year down the line, we’ll be using all three vaccines with about 90 percent protection — and we’ll be a lot happier,” said Danny Altmann, professor of immunology at Imperial College London.

Late-stage trials in the UK and Brazil showed the vaccine’s effectiveness depended on the dosing — with the cheaper option proving more effective.

With two doses, the effectiveness appeared to be just 62 percent — but was 90 percent effective in preventing COVID-19 when it was administered as a half dose followed by a full dose at least one month apart.

There were no hospitalizations or severe cases of COVID-19 reported in those receiving the vaccine.

“These findings show that we have an effective vaccine that will save many lives,” Oxford University Professor Andrew Pollard, chief investigator for the trial, said in a statement.

FBD
11-23-2020, 03:13 PM
still not taking it

lost in melb.
11-28-2020, 03:18 AM
Great

deebakes
11-28-2020, 05:18 AM
Sort of weird:

A highly anticipated COVID-19 vaccine has delivered some encouraging — but head-scratching — results. The vaccine developed by the University of Oxford, UK, and pharmaceutical giant AstraZeneca was found to be, on average, 70% effective in a preliminary analysis of phase III trial data, the developers announced in a press release on 23 November.

But the analysis found a striking difference in efficacy depending on the amount of vaccine delivered to a participant. A regimen consisting of 2 full doses given a month apart seemed to be just 62% effective. But, surprisingly, participants who received a lower amount of the vaccine in the first dose and then the full amount in the second dose were 90% less likely to develop COVID-19 than were participants in the placebo arm.

https://www.nature.com/articles/d41586-020-03326-w

Godfather
11-28-2020, 06:13 AM
Sort of weird:

A highly anticipated COVID-19 vaccine has delivered some encouraging — but head-scratching — results. The vaccine developed by the University of Oxford, UK, and pharmaceutical giant AstraZeneca was found to be, on average, 70% effective in a preliminary analysis of phase III trial data, the developers announced in a press release on 23 November.

But the analysis found a striking difference in efficacy depending on the amount of vaccine delivered to a participant. A regimen consisting of 2 full doses given a month apart seemed to be just 62% effective. But, surprisingly, participants who received a lower amount of the vaccine in the first dose and then the full amount in the second dose were 90% less likely to develop COVID-19 than were participants in the placebo arm.

https://www.nature.com/articles/d41586-020-03326-w

Ya this seems like a setback. I'm still saying, if you're putting money on stocks here, bet on Novax (ticker symbol is $NVAX). A few reasons I say this:

1) Moderna has to be at -20c, Pfizer at -70c, Oxford-Astra/Zeneca was promising but has had this setback. Novax just needs to be kept at -2c.

2) Another consideration is that these top candidates appear to have 90+% prevention of symptomatic disease and not 95% prevention. Novax has and edge here. Based on pre-clinical and Phase 1 clinical data Novax appears to be be significantly better at not only preventing symptomatic disease, but also preventing transmission.

3) AND Novax is the only vaccine that can be multiplexed with a flu vaccine resulting in a long-term revenue stream beyond the initial wave of vaccination


Whether or not you're getting one of these vaccines, if you're an investor, I suggest you strongly consider the horse to bet is Novax.