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View Full Version : Humans will NEVER live past 125 years: The body cannot naturally pass beyond a certain life expectancy



Teh One Who Knocks
10-07-2016, 11:48 AM
By Colin Fernandez Science Correspondent For The Daily Mail


http://i.imgur.com/QovTPOw.jpg

The natural limit to human life is no more than 125 years, a study has found.

Despite ever more humans living for longer each year – the final cut-off point has remained stubbornly the same.

No human has lived longer than 122 – the age reached by a Frenchwoman, Jeanne Calment, in 1997.

Researchers believe that this is because there is an age limit beyond which humans just cannot pass naturally.

Researchers led by Jan Vijg of the Albert Einstein College of Medicine in the Bronx, New York investigated whether the rise in human lifespans meant the 122 lifespan was a maximum.

The most 'convincing argument' that the maximum human lifespan is not fixed is the ongoing increase in life expectancy in most countries over the last century, the researchers said.

However, a large part of the increase in life expectancy comes from a huge reduction of deaths in childbirth and infancy.

http://i.imgur.com/2c3H1cX.jpg

If there was no limit, we would see an onward march of ever older people.

To test the theory, they studied the International Database on Longevity, which records the age of death from people in 41 countries between 1968 and 2006.

They found that people do keep living longer – but only up to a point.

They said: 'the rate of improvement in survival peaks and then declines for very old age levels which points towards diminishing gains in reduction of late-life mortality and a possible limit to human lifespan.'

'In contrast to previous suggestions that human longevity can be extended ever further, our data strongly suggest that the duration of life is limited,' the researchers wrote in Nature.

They said despite the huge improvements in life expectancy seen in the past 150 years, 'improvements in survival with age tend to decline after age 100,' and that the age at death of the world's oldest person has not increased since the 1990s.

Their findings were also supported by maximum recorded age of death figures in another database, that of the Gerontological Research Group, which records deaths from 1972 to 2015.

This database shows that each year, the maximum recorded age of death for the countries in the database 'plateaued' in 1994 at an average of 114, It has slightly decreased since then.

They estimate 125 as an upper limit: but stress it would be rare.

They estimate the chance of anyone living longer than Jeanne Calment, and recording a maximum age of 125 for any given year would be once in 10,000 years.

Mrs Calment, the oldest documented human to ever live, chalked up the remarkable age of 122 years and 164 days in 1997.

She greatly outlived her husband, who died at 73, and only gave up cycling when she was 100.

She smoked two cigarettes a day, only giving up five years before her death.

In 1877, as a girl of 13, in her hometown of Arles, she recalled selling pencils to Vincent Van Gogh, who lived nearby, who was 'dirty, badly dressed and disagreeable.'

The UK, France, Japan and the US have the most supercentenarians – people aged 110 years or more.

Average life expectancy is 81.50 years in the UK.

There have been 134 verified supercentenarians from the United Kingdom.

The oldest living person in the United Kingdom is Bessie Camm from Rotherham, born 20 June 1904, aged 112 years, 107 days as of today.

deebakes
10-07-2016, 01:11 PM
:lol: i know all of the authors on this paper, i was just at albert einstein two weeks ago giving a seminar there :tup:

Teh One Who Knocks
10-07-2016, 01:18 PM
Are they right? :-k

deebakes
10-07-2016, 01:29 PM
overall, the data support the conclusion at this stage. genetic traits that would be advantageous later in life were never part of the selection process during evolution, as selection only works during the reproductive phase of any organisms life. with all of the interventions that have happened over the years, ultimately aging wins and causes deterioration in most tissues. according to stats, if we were able to cure ALL forms of cancer today, it would extend the median lifespan of people by ONLY 3-5 years, which i thought was shocking. even if you were able to prevent all cancer deaths, people would still die from cardiovascular disease or something else. until we can develop therapies to alter the aging process as a whole, it is likely that there is a cap to human lifespan. this lady also died almost 20 years ago, one would expect that there would have been someone to live past this age if we were having strategies to overcome the currently accepted maximum.

Teh One Who Knocks
10-07-2016, 01:34 PM
Do you think there is any way to slow down or stop the degeneration in cells (as we age) that would be able to lengthen the human lifespan? To say maybe 200 years?

deebakes
10-07-2016, 01:45 PM
what my lab actually works on is eliminating (or preventing) aged, damaged cells from tissues to test how this influences age-related deterioration. doing so extends the life of mice by 25%, we now have a company that is focused on removing these cells from diseases where these cells accumulate, like osteoarthritis. ultimately, the FDA does not recognize aging itself as a disease, which means all of the anti-aging therapies are not approved. the drugs have to be designed to treat a disease (ie cardiovascular disease), but if it ultimately impacts the aging process, it could be a fortuitous side effect. i think we can extend, but it will probably be a relatively slow process, not a sudden intervention that instantly extends lives by decades. 200 might be pushing it, but in reality, if you were alive until 200, but unable to do what you wanted to do and didnt remember anyone, would you actually want that? my lab focuses on increasing years of healthy life, which i think is more important.

there are a couple crazy people out there that think we can live to be 1000. if you are interested, there is an interesting (keep in mind i'm a fucking dork though, so maybe it will not be appreciated) documentary on netflix called the immortalists (http://theimmortalists.com/). i've received funding from the SENS foundation that was founded by one of the main people that they follow in the show (Aubrey de Grey, dude with the huge beard, he is quite the character in real life).


https://www.youtube.com/watch?v=BDlVY8iLCek

Teh One Who Knocks
10-07-2016, 01:50 PM
Very cool stuff Dee, I'll try and check it out sometime :thumbsup:

Hikari Kisugi
10-07-2016, 02:36 PM
What about Telomeric transfers that sort of thing, surely within a thousand years we'll have perfected genetic manipulation on a cellular level, then the only issues will be clearing plaques and various heavy metals other nasties from non-dividing cells.

No point being 500 if you're ga-ga.

redred
10-07-2016, 02:53 PM
i'm not to sure i'd like to live that old

Muddy
10-07-2016, 03:21 PM
What about Progeria? It would seem if it turns on, that mechanism would be something that could be turned off.. Once you can do that couldn't that knowledge be applied to stopping the aging process?

perrhaps
10-07-2016, 11:39 PM
This is sad. At best, I'm officially more than half-dead.

lost in melb.
10-08-2016, 04:24 AM
Dee actually has a job?:jawdrop:

lost in melb.
10-08-2016, 04:27 AM
http://tmhome.com/benefits/study-tm-meditation-increase-telomerase/

deebakes
10-08-2016, 04:51 AM
:bwaha:

Godfather
10-08-2016, 07:40 AM
Man and I was all optimistic about humans living a long ass time after that TED talk years ago (one of the most famous ones by the dude with the pony tail)...

Anyways, great reply Dee, interesting stuff.